วันพฤหัสบดีที่ 22 กันยายน พ.ศ. 2554

human genome project


human genome project 


Human Genome Project: -. 1991 Michael Coe wrote Breaking Maya Code, which he said knowing how this language was' both phonetic and graphic it was important that the Human Genome Project and the settlements in the area, I personally think that it is very important to see that the Mayas were the language to understand the many possibilities, many tribes and people.
human genome project videos

It is very important for our application to the Brotherhood. It is not as important as any other important step forward in the future of humanity is the space go colonization of our salvation, and the remnants of humanity, even if it the Mayan prophecy that 2012 offers a new interpretation of human civilization on earth. I personally hope that the prophecy refers to the new location, and people. you need a ethical approach, the Human Genome Project. We should not be forced to a small group of people, some of the new species, although I think it would be best for them and together for all of us. Those who want to pass the immortality gene therapy and the strengthening of the telomeres, which is not in a position to gay sapiens immortalis when all people have access. How can we prevent it? What is human cloning? Then there's Danny Hillis and who want to get rid of their brains, a stunning work to be completed. This is not a textbook of science fiction, but it must take place at the time, or at least his father's generation.
human genome project definition


"The genetic blueprint for a person less than 21 / 2 inch length of 1.8 m of DNA that fills the interior of each cell in the body according to new results. Most of the other human genome is full of strange life of individuals have found that the holders of the genome as tiny fragments of foreign DNA {Gardner says some is Anunnaki or alien DNA, and the white side is more programming.} Living parasites human DNA and even smaller pieces of sponge and parasite. Although already on the creature in the human genome, only now to see how many people actually know how the genes are transmitted to humans, and how these communities in the development of complex cells from human ancestors millions of years ..
human genome project pbs


"We called the human genome, the book of life, but in fact three books," said Francis Collins, director of the National Human Genome Research Institute in Bethesda, Maryland, and Director of the Human Genome Project. "This is a history book. This workshop manuals and parts list. Y "is a textbook of medicine, a deeper more detailed than ever .'..

The researchers also found that sperm mutations twice as many eggs, which means that people suggested the major source of errors in the genetic and evolutionary innovations.
nova human genome project


By comparing the human genome with the genomes of simple organisms like flies and worms, scientists have also unprecedented detail view, helped a handful of genetic innovations, the first vertebrates start of all the hundreds of millions of years before the organic.

If the evolutionary creativity that led to the human genome, researchers, he says, surprisingly few changes in a person. Worldwide, 99.9 percent genetically identical. "(10)

Do you think there is much to consider, learn how to become the white man, or how the hominids were not as modern as us? It seems that a lot of information in our genes. It could be access to a computer that leads the soul? I think swimming is the energy situation and the Akasha and through life. NASA scientists that life is everywhere, and I can say that the love is there. If you just do not get to feel and the feeling of "warmth that permeates every void and fills every rock world. Shamans in their second-line drugs and to maintain the direction, plants and stones. Jung's archetypes of the genes lead to our past. Perhaps Jesus and his father to live "close, we give our genes. Mystics claim that genes, the involvement of the soul and spirit. Our network archetypes, or "one-dimensional harmonic force ', 11, M-membranes in each atom, the coordination of our solar system body and the dross physical bodies. It is ridiculous to think that we all know the consciousness and the soul, and most people live in ignorance or deny its presence. "

Trips made when we become aware of the soul of the body of the sun and traveling are incorporated impressive. It is surprising that the grimace on the face of a professor who does not agree with these ideas. Poets and troubadours of the past, we were able to bring our ideas to hell when he starts dancing in harmony with nature. The natural forces of cohesion and the meridians or rust, and vectors that enable the operation of all is wonderful. We have tried to put us in nature and will never want to (hopefully) to be selfish. These forces do not say hello to us we will dive the reef. Victor Hugo wrote a wonderful appreciation of Shakespeare, which I quote. In comparing the perceptions of Shakespeare, at the foot of the cliff, overlooking the "vision of waves wonderful!" Every time we read his works again, that the depth of experience and back to the cliff and a little more that brings us one step closer to reality, all the waves in the cosmic ocean that awaits us in connection Beauty at the end of our journey has .

วันอาทิตย์ที่ 11 กันยายน พ.ศ. 2554

sequencing of dna


sequencing of dna 



New DNA Diagnostic Test For Lyme Disease May Have Merit
Milford Hospital in Massachusetts has been working for over a year on a new type of diagnostic test for Lyme disease using sequencing of dna  rather than DNA nesting.

Huh?

We have all heard of the polymerase chain reaction (PCR) method of Lyme testing which is considered a "DNA nesting" test method which detects a genomic DNA of the Lyme disease-causing spirochete in the blood.
dna sequencing technology


There are many problems with the PCR test but the largest being (in my opinion) that by the time a person is diagnosed by the ELIZA antibody test and then the western blot, a PCR will likely be negative due to the time it takes for the spirochetes to disseminate into the victim's body.

If however, this new sequencing of dna  test could replace the ELIZA test and be administered immediately, we would have a much better chance of diagnosing Lyme early, treating it early and reducing the number of missed cases that end up as debilitating chronic cases.

Excitement is growing around this new test for several reasons.



First, in the world of genetic testing, sequencing of dna  is accepted as the gold standard for molecular identification wheras the ELIZA test is considered to miss as many as 50 - 75% of those who are infected.

Secondly, at a time where battle lines have been clearly drawn in the medical sands of research and practice, the staff and research team under Dr Lee, a pathologist at Milford Hospital (Milford, CT), Dr. Jay Walshon, Chairman of Emergency Medicine at Milford Hospital, and Dr. Jessie Williams, of the Milford Hospital Walk-in Urgent Care Center are preparing another report to summarize their research experience.

Perhaps at another time this would not be remarkable, but to see that these papers are being published can give us all hope that eventually research will over-run prejudice and give the doctors who are caught in the crossfire, wanting to treat their patients who are suffering so severely with chronic Lyme - but feel their hands are tied by the harsh and restrictive language of the IDSA.
dna sequencing diagram


I believe most of our doctors do care and truly want to help but feel they are backed up against the wall given the hostility of the existing argument.

So we will keep a watch out for the next press release from Milford Hospital.

Meanwhile, if you or someone you know believes they may have contracted Lyme disease recently, this new test is being used right now in Milford.

The physicians at the Milford Hospital Emergency Center and Walk-in Urgent Care Center, who see about 40,000 patients a year, usually order the traditional antibody testing and the new DNA test for patients presenting with Lyme disease-like symptoms. Evidently, most insurance companies except Aetna will pay for the test.

วันพุธที่ 7 กันยายน พ.ศ. 2554

mtdna sequencing

mtdna sequencing
The completion of human mtDNA sequencing project was the first step in allowing scientists to unravel the secrets contained in our DNA sequencing. Further over the past few years DNA testing has become affordable and easy to do. This has spawned the practice of performing DNA testing for Genealogical purposes which is called Genetic Genealogy.

One of the first genetic genealogy studies was conducted in the late 1980s by scientists with the Department of Biochemistry at the University of California, Berkeley. These scientists Rebecca L. Cann, Mark Stoneking and Allan C. Wilson studied a newly discovered kind of DNA. Mitochondrial DNA (mtDNA sequencing) is contained not in the nucleus of our cell, but in the mitochondria organelles of our cells. These scientists chose to study Mitochondrial DNA (mtDNA) because of its three unique properties which they explain as:
DNA sequencing
First, mtDNA sequencing gives a magnified view of the diversity present in the human gene pool, because mutations accumulate in this DNA several times faster than in the nucleus. Second, because mtDNA sequencing is inherited maternally and does not recombine, it is a tool for relating individuals to one another. Third, there are about 1016 mtDNA molecules within a typical human and they are usually identical to one another (Cann 31).

They extracted and compared mtDNA from "147 people, drawn from five geographic populations" (Cann 31). The researchers discovered that "All these mitochondrial DNAs stem from one woman who is postulated to have lived about 200,000 years ago, probably in Africa" (Cann 31). Their findings also agree with the archaeology record as Cann explains "Studies of mtDNA suggest a view of how, where and when modern humans arose that fits with one interpretation of evidence from ancient human bones and tools" (36).
mtDNA

Swedish researchers Max Ingman, Henrik Kaessmann, Svante Paabo and Ulf Gyllensten critical of these findings conducted their own study in 2000. They claimed that "almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome" (Ingman 708). Further they argued that the prior methods of analysis where "providing data that are ill suited to estimations of mutation rate and therefore the timing of evolutionary events" (Ingman 708). So they decided to study the complete mtDNA sequence from 53 people of various races.

Surprisingly their attempt to discredit the previous research failed as they also came to roughly the same conclusions. They conceded to the likely hood of a common ancestor shared by all the subjects despite being "geographically unrelated" (Ingman 712). They estimated "The age of the most recent common ancestor (MRCA) for mtDNA, on the basis of the maximum distance between two humans...to be 171,500" (Ingman 712) instead of the earlier estimate of 200,000 years ago. But they refused to align their findings with archeologists by stating "Whether the ancestors of these six extant lineages originally came from a specific geographic region is not possible to determine" (Ingman 712). Lastly they agreed on the potential of genetic genealogy by summarizing:

    Our results indicate that the field of mitochondrial population genomics will provide a rich source of genetic information for evolutionary studies. Nevertheless, mtDNA is only one locus and only reflects the genetic history of females. For a balanced view, a combination of genetic systems is required. With the human genome project reaching fruition, the ease by which such data may be generated will increase, providing us with an evermore detailed understanding of our genetic history (Ingman 712).

Their call for a more balanced view was shortly answered because in 2000 a team of researchers from the Department of Genetics at Stanford University lead by Peter A. Underhill published their results of studying Y-chromosome DNA. Only males have the Y-chromosome which has unique properties as explained by Underhill:

    Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history (358).

Their report was based upon "the analysis of 1062 globally representative individuals" (Underhill 358). They concluded that the subjects "represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago" (Underhill 358).

So far genetic genealogy research has focused on these two kinds of DNA. As mentioned previously mtDNA is passed along the maternal line and Y-Chromosome DNA is passed along the paternal line. These two kinds of DNA effectively encompass all of our ancestors. Yet they provide no information about our ancestors inside the encompassed area. For example our maternal grandfather (mother's father) couldn't contribute any mtDNA or Y-Chromosome DNA to our mother. Yet he did contribute a third type of DNA called autosomal DNA. This type of DNA has yet to be studied for Genetic Genealogy purposes because of its inherent difficulties.

The main reason autosomal DNA is just now being studied is because scientists aren't sure how to determine which autosomal DNA came from mom and which came from dad without testing one or both of our parents. This situation is illustrated by the mathematical equation X = Xm/2 + Xd/2 where our autosomal DNA (X) is half of our mom's (Xm/2) and half of our dad's (Xd/2). By testing ourselves we identify our autosomal DNA but can't determine which part came from mom or dad. Additionally testing one of our parents is necessary to determine exactly which parent contributed which part of our autosomal DNA. This type of testing is currently used for Paternity and near relationship testing. But quickly becomes impractical after a few generations because of the difficulty of obtaining DNA samples from probably deceased ancestors.

Conclusion
analyzing mtDNA

Genetic Genealogy is the science of analyzing mtDNA sequencing for genealogical purposes. Studies have shown that we all stem from a common female and male ancestor. Because this emerging science is so new, benefits of this research are still being identified. Currently I believe Genetic Genealogy offers three categories of benefits.

First is entertainment value. Finding out you're related to famous people like George Washington, Julius Caesar or Genghis Khan is just plain fun. Imagine the bragging rights and small-talk fodder this provides at social gatherings.



Second is scientific value. Current studies have corroborated other scientific findings such as the human archaeological record. Medical sciences will benefit from correlating mtDNA sequencing studies with family genealogies to isolate hereditary diseases.

Third is relatedness value. Finding out you're related to a wealthy individual like Bill Gates may entail a financial windfall. Most importantly of all is the ability to reunite families. Millions of displaced war torn families and adopted children can now turn to Genetic Genealogy to find their relatives.

Article Source: mtdna sequencing

วันอาทิตย์ที่ 4 กันยายน พ.ศ. 2554

the human genome project

the human genome project
My nephew has a doctorate in "Studying all that Biological Stuff."
After his mother's funeral at dinner I asked him how the human genome project was going and was he working on it.
He is very quiet and uses short sentences if possible. He said, "We finished that."
I changed the subject to Latent Hopes of Tibetan Monks, where I have more expertise. You don't want to look too stupid to your smart nephew.

 the human genome project videos
Anyway, it still nagged me that I knew so little about the Human Genome Project. After almost two years of this nagging I decided to look up Human Genome on Google, my favorite place to look up the strange and obvious.
Well, that was a downright lie. That's not why I looked it up. The real reason was I learned that the Department of Energy was involved. (That was before I remembered that DOE has these gigantic computers that can handle complex projects like the HGP.) I decided there was another governmental conspiracy we had not learned about. It smelled like Vice President Dick Cheney's Cabal again. They were going to turn some of us humans into pillars of oil.
At my friend's house, Mr. Google.com, I looked at the top entry which often is as far as I want to dive into 10 zillion submissions. It seems that everybody in the universe knows more about the human genome than I do and each one has written at least one article or web page for the Internet.

Article Source: the human genome project

วันพฤหัสบดีที่ 1 กันยายน พ.ศ. 2554

dna sequencing facility


dna sequencing facility
dna sequencing facility
In recent decades, the impressive development of genetic engineering. The proposal to sequence the entire human genome was created 16 years ago to interpret "arms race" between public and private companies with no natural sciences. In a constant battle for the first version of the human genome, a multinational consortium, and public companies, biotechnology, which is owned by billionaire Craig Venter billion to publish new DNA sequencing technology quickly and accurately develop. It has brought enormous benefits for biological and medical research and improve treatments and diagnostic tools.
Genetic testing is one of the fields that greatly benefited from these outcomes. As we know from famous TV series, today is possible to finger out a criminal by analyzing a single hair or a tiny drop of saliva. A more widespread application of this technology is that of paternity testing. A doubtful father can easily order a DNA testing kit, take a sample of himself and his child and send it out to a DNA testing facility. In a matter of days, he will receive a report confirming of ruling out his biological fatherhood on that child.
dna analysis facility

Although establishing paternity is the most frequent reason for having a DNA test done, there are many other applications. For example, it is also possible to determine other familiar relations such as brother/sisterhood, maternity, paternity when the alleged father is not available and so on. People can also have a detailed analysis about their ethnic and genealogical background. These kinds of tests are often made out of curiosity, but sometimes they can be very helpful. It is frequent that people are excluded from certain benefits that are intended for a specific ethnic group, such as Native Americans because they cannot demonstrate their ancestry. DNA testing is an effective and conclusive way to prove a person's ethnic ancestry.
genome sequencing service

So far, everything looks fine. You need to have a DNA test done, so you do some research online. What you will find is an overwhelming spectrum of DNA labs offering paternity tests, and of course, each of them claims that they are "the best lab". What to do? Pick the first you come across? Pick the cheapest? You don't need to be an expert to decide, but knowing the difference among all those labs will allow you to make a wiser decision. Why is this important? The kinds of questions you seek to answer through a DNA test are not trivial. A man who is not sure if he is the true father of his children cannot accept a "maybe" as an answer, can he? Well, that is what he'll get if he chooses a cheap DNA test from an inexperienced lab.
All DNA tests are essentially similar in their bare basics: they are all based on the same biological principles and use the same kind of analytical methods. There are, however, some differences you should take into account.

One important difference is the number of genetic markers they look at. Genetic markers are simply specific regions in the human genome that tend to be different among people. Imagine there is a region for which there are 5 different "types" among humans. You are most likely to have the same type as your father at the same region. However, since there are only 5 different types in the population, your are also sharing the type with many other people that are not related to you, so that looking at this single region will not tell for sure who your father is. If we look at another region, the chances for sharing both of them with unrelated people are lower, but it is still possible.
dna analysis facility

As the number of markers increase, the probability of a random match (sharing the same markers with an unrelated person) is lower. The best paternity tests use as much as 16 different markers. Having a match for all 16 markers by chance is virtually impossible, so a perfect match conclusively tells that the two persons are father and child. Why not using even more markers? Because there is no need to (with 16 markers, the probability of a false result is nil), and adding more markers to the analysis would only make the test more expensive. Why not less than 16? Many labs use between 4 and 8 markers to make the test cheaper. By choosing one of these you may save a few dollars, but your doubts will not be completely wiped out. Do you find this acceptable? Surely not.
The second most important source of false results of DNA testing is, paradoxically, one of its strengths. DNA tests are based on a technique called PCR (for Polymerase Chain Reaction). PCR was a revolutionary invention that warranted its creator a Nobel Prize. One of the most important features of PCR is its sensitivity: it is possible to analyzed minute amounts of DNA (in theory it can be done with a single cell). On one side, one can analyzed DNA from a single hair, a tiny spot of blood or even from the saliva obtained from a used cigarette, but the high sensitivity has a downside: it is very easy that such small samples become contaminated with DNA from other individuals, such as the police detective that gathered blood spots at the crime scene, the lab technician who processed the sampled and so on. Truly professional DNA labs follow strict guidelines and protocols to avoid contamination and have University-trained personnel. In this regard, if you send your DNA sample to an inexperienced or ill-equipped DNA lab, you risk a false result since somebody else's DNA may be analyzed instead of yours due to improper manipulation or use of cheap or defective lab materials.

dna sequencing

If you are thinking of having a DNA testing done, being for establishing paternity, genealogical inquiry, determination of Native American status or other reasons choose carefully. Avoid labs offering very low prices. Check thoroughly to have an idea about the price ranges out there. Only labs offering a multi-marker (ideally 16 for the standard paternity test) tests should be trusted. Avoid labs that, judging from their websites appear to be small or amateur. Consider that some companies are offering "ready-to-use" DNA testing labs that can be used by anyone to offer cheap DNA testing. DNA testing should only be performed by qualified personnel and equipment.

Article Source: dna sequencing facility